Pure Red Cell Aplasia as an Autoimmune-mediated Disorder
نویسندگان
چکیده
منابع مشابه
Pure red cell aplasia as an autoimmune receptor disease.
To the Editor: Suppression of the erythroblastic compartment in the bone marrow is the hallmark of pure red cell aplasiaL2 (PRCA). The demonstration of IgG inhibitors of erythropoiesis2 has given a clear indication of the autoimmune pathogenesis of the disease. Indeed, two types of PRCA have been distinguished recently,5 the first with autoantibodies directed against the erythroid marrow and th...
متن کاملEpoetin-induced autoimmune pure red cell aplasia.
During the first 10 yr of therapy with recombinant human erythropoietin ([EPO]), only three cases of antibody-associated pure red cell aplasia have been described in patients who were treated with EPO, whereas several millions of patients have received this treatment. Thus, the possibility for epoetin to induce the formation of anti-EPO antibodies was considered extremely low. However, since 19...
متن کاملAcquired pure red cell aplasia.
Correspondence MEDICALTJOSRNAL 559 Acquired Pure Red Cell Aplasia SIR,-May we make the following observation about your article on acquired pure red cell aplasia and its treatment with steroids (6 April, p. 3) ? A pure red cell aplasia that responded to riboflavine or prednisone has been described in African adults and in children with marasmus and kwashiorkor.' In marasmus and kwashiorkor an e...
متن کاملStudies on Pure Red Cell Aplasia
An 1 8-yr-old female with chronic active The patient’s plasma was cytotoxic for hepatitis developed a severe anemia due erythroblasts. Following splenectomy, a to a lack of red cell production. Her bane remission of the disease occurred. This marrow showed many large proerythrostudy indicates that in some cases the blasts but an almost complete lack of more anemia associated with abundant marro...
متن کاملAzathioprine-induced pure red-cell aplasia.
Long-term administration of azathioprine is widely used to prevent rejection in organ transplantation and in the treatment of autoimmune diseases. Bone marrow toxicity is a well-known side-effect of azathioprine. Macrocytosis, with or without megaloblastic erythropoiesis in the bone marrow, and (mild) leukopenia are frequently seen [1-4]. Less common effects are anaemia, thrombocytopenia and pa...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 2002
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.41.507